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Dictionary
Definitions from Oxford Languages · Learn more
sus
INFORMAL
adjective
1.
giving the impression that something is questionable or dishonest; suspicious.
"it's a little sus that he seems to know exactly how to play this game"
2.
HISTORICAL•BRITISH
relating to or denoting a law under which a person could be arrested on suspicion of having committed an offence.
"the sus law"
nounBRITISH
suspicion of having committed a crime.
"he was picked up on sus"

[OnTheHorizon143]

Great, now we are doing definitions

[Creeperopolis]

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.[1] Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products.[2] An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction.

An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. By contrast, reversible inhibitors bind non-covalently and may spontaneously leave the enzyme, allowing the enzyme to resume its function. Reversible inhibitors produce different types of inhibition depending on whether they bind to the enzyme, the enzyme-substrate complex, or both.

Enzyme inhibitors play an important role in all cells, since they are generally specific to one enzyme and serve to control that enzyme's activity. For example, enzymes in a metabolic pathway may be inhibited by molecules produced later in the pathway, thus curtailing the production of molecules that are no longer needed.[3] This type of negative feedback is an important way to maintain balance in a cell.[4] Enzyme inhibitors also control essential enzymes such as proteases or nucleases that, if left unchecked, may damage a cell. Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators.

Many drug molecules are enzyme inhibitors that inhibit an aberrant human enzyme or an enzyme critical for the survival of a pathogen such as a virus, bacterium or parasite. Examples include methotrexate (used in chemotherapy and in treating rheumatic arthritis) and the protease inhibitors used to treat HIV/AIDS. Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side effects in humans, provided that no analogous enzyme is found in humans. (This is often the case, since such pathogens and humans are genetically distant.) Medicinal enzyme inhibitors often have low dissociation constants, meaning that only a minute amount of the inhibitor is required to inhibit the enzyme. A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in humans. Hence the discovery and refinement of enzyme inhibitors is an active area of research in biochemistry and pharmacology.[5]

[OnTheHorizon143]

Enzyme inhibitors? I learned that in school!

[Creeperopolis]

Proteus is a 2013 exploration and walking simulator video game designed and created by Ed Key and David Kanaga for Microsoft Windows, OS X, Linux, PlayStation 3 and PlayStation Vita. In the game, the player traverses a procedurally generated environment without prescribed goals. The world's flora and fauna emit unique musical signatures, combinations of which cause dynamic shifts in audio based on the player's surroundings.

The game began development in 2008. Key first conceived Proteus as an open-ended role-playing game akin to The Elder Scrolls IV: Oblivion but, because of the work required for such a project, later redesigned it to be "nontraditional and nonviolent". Audio designer and composer David Kanaga joined the project in 2010. Versions for the PlayStation 3 video game console and Vita handheld console were developed by Curve Studios, whose team added new gameplay features to the Vita edition at Sony's request.

Proteus won the prize for Best Audio at the 2011 IndieCade awards, and was a finalist for the 2012 Independent Games Festival's Nuovo Award. Following its release, critics praised the game, especially for its audio features, although some criticised the game's brevity and limited replayability. The game was frequently mentioned in discussions of video games as art, with some debating whether it could be considered a video game at all.

[OnTheHorizon143]

Best audio?

[Priyanjan]

What Remains of Edith Finch is a first-person exploration video game developed by Giant Sparrow and published by Annapurna Interactive. The game was released in April 2017 for Microsoft Windows, PlayStation 4, and Xbox One; for Nintendo Switch in 2019; for iOS in 2021; and for PlayStation 5 and Xbox Series X/S in 2022.

The story follows the seventeen-year-old Edith Finch, the last surviving member of her family, as she returns to her ancestral home for the first time in seven years. Reexploring the house, she uncovers her family's mysterious past and learns about the series of deaths that eventually caused the complete collapse of her family structure. The game is presented as an interconnected anthology, and, utilizing unique mediums from varying perspectives, the story is told through a series of vignettes; however, the player is made to doubt the authenticity of each story being told.

What Remains of Edith Finch received critical acclaim, receiving praise for its immersive storytelling, characters, and presentation; and is considered an example of video games as an art form. Among other awards and nominations, It won British Academy Games Award for Best Game 2017 and the Best Narrative category at both The Game Awards 2017 and the 2018 Game Developers Choice Awards.

[OnTheHorizon143]

4

[Creeperopolis]

23 Wall Street (also known as the J.P. Morgan Building) is an office building in the Financial District of Manhattan in New York City, at the southeast corner of Wall Street and Broad Street. Trowbridge & Livingston designed the four-story building in the neoclassical style. Constructed between 1913 and 1914, it was originally the headquarters of J.P. Morgan & Co. Since the late 2000s, the building has remained unoccupied for long periods, although it has occasionally been used for events.

The building has a facade of ashlar masonry and pink Tennessee marble. The first floor consists of a piano nobile over a low basement; above it are the second story, the main cornice, and two more stories. After its completion, the building became known as the headquarters of J.P. Morgan & Co.—the "House of Morgan"—although its exterior was never signed with the Morgan name. The banking room, which took up nearly the entire ground floor, included offices and was used for banking transactions. This space was designed with a domed, coffered ceiling and, later, a large crystal chandelier. Mechanical systems and vaults were in the basement, and executive offices were placed on the upper floors.

23 Wall Street replaced the Drexel Building, which was the banking headquarters for J.P. Morgan & Co.'s predecessor Drexel, Morgan & Co. When the building was damaged during the Wall Street bombing in 1920, J.P. Morgan & Co. refused to make repairs, in defiance of the bombing's perpetrators. The building was linked to neighboring 15 Broad Street in 1957, and the two buildings served as the J.P. Morgan & Co. headquarters until 1988, when the firm moved to 60 Wall Street. During the 2000s, there were plans to convert both 23 Wall Street and 15 Broad Street into a condominium complex. In 2008, 23 Wall Street was sold to interests associated with the billionaire industrialist Sam Pa but mostly remained empty afterward.

Depicted in several media works, 23 Wall Street's simple design was generally praised upon its completion. The building is a New York City designated landmark and is listed on the National Register of Historic Places (NRHP); it is also a contributing property to the NRHP-listed Wall Street Historic District.

[Creeperopolis]

The Delaware Tercentenary half dollar (also known as the Swedish Delaware half dollar) is a commemorative fifty-cent piece struck by the United States Bureau of the Mint to commemorate the 300th anniversary of the first successful European settlement in Delaware. The reverse features the Swedish ship Kalmar Nyckel, which brought early settlers to Delaware, and the obverse depicts Old Swedes Church, which has been described as being the oldest Protestant church in the United States still used as a place of worship. While the coins are dated "1936" on the obverse and the reverse also has the dual date of "1638" and "1938", the coins were actually struck in 1937.

Authorizing legislation for the coin passed Congress in early 1936. Although there was no opposition, the legislation was changed to add protections for collectors against abuses, such as low mintages or strikings at multiple mints, which marked some commemorative coins at that time. Once the coin was authorized, the Delaware Swedish Tercentenary Commission (DSTC) held a competition to design the coin, judged by Mint Chief Engraver John R. Sinnock and sculptor Dr. Robert Tait McKenzie, which was won by Carl L. Schmitz.

The coins were produced at the Philadelphia Mint in March 1937, and were then sold to the public by the DSTC for $1.75 each. Of the 25,000 coins minted for sale, 20,978 were sold, and the profits used to help fund the tercentenary celebrations. The Delaware Tercentenary half dollar sells in the low hundreds of dollars, though exceptional specimens have sold for more.